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SHWE-HSB Cell Culture Supplement, Lyophilized
Catalogue no.SHWE-HSB · Carbohydrate polymer from Arthrospira (Spirulina)
Product Overview
SHWE-HSB is a purified polysaccharide polymer isolated from Arthrospira (Spirulina) microalgae. Unlike conventional extracellular matrix proteins such as fibronectin, laminin, or RGD peptides, SHWE-HSB is entirely plant-derived and free of animal components, offering consistent, lot-to-lot reproducibility without the batch variability inherent in protein-based matrices.
NMR analysis confirms SHWE-HSB is a single, negatively charged polymer with a molecular weight between 280 and 320 kDa. Its exceptional stability, maintaining integrity up to 100°C and across a pH range of 2 to 12, makes it compatible with sterilisation conditions and a wide variety of downstream formulations.
When incorporated into hydrogels, SHWE-HSB significantly enhances stem cell proliferation compared to unmodified matrices. As a surface coating, it reduces contact angle from 62° to 9° on ultra-low attachment surfaces, substantially improving cell adhesion without the need for animal-derived proteins.
Specifications
| Product name | SHWE-HSB Supplement, Lyophilized |
| Catalog number | SHWE-HSB |
| Product type | Carbohydrate polymer (polysaccharide) |
| Source organism | Arthrospira sp. (Spirulina) microalgae |
| Form | Lyophilized powder |
| Color | Light yellow to pale white |
| Molecular weight | 280–320 kDa (NMR confirmed) |
| Charge | Negatively charged, single polymer |
| Thermal stability | Stable up to 100°C |
| pH stability | pH 2–12 |
| Solubility | ~8 mg/mL in sterile water (slight cloudiness is normal) |
| Recommended working conc. | 1–3 mg/mL (hydrogel); optimise per application |
| Pack size | 10 mg |
| Shipping | Ambient temperature |
| Intended use | Research use only / for further manufacturing |
Figures
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The proliferation of neural stem cell (NSCs) encapsulated in different hydrogels for a period of 14 days. *p <0.05, **p <0.01, and ***p <0.001 between the indicated group (G1: 1mg/ml, G2: 3mg/ml, G3: 5mg/ml) -
Potential clustering behaviors of NSCs encapsulated in four different hydrogels on day 6 and day 14. Red arrows represent the neuro-clusters. -
Left: The average contact angle values for the untreated non-adhesive dish and the HSB-modified dish.
Right: Cell adhesion behaviors of NSCs within 48 hr on the untreated non-adhesive dish and the HSB-modified dish.
References and Citations
Xu, J.; Hsu, S.-h. Enhancement of Cell Behavior by the Polysaccharide Extract of Arthrospira and Potential Biomedical Applications. Molecules 2023, 28, 732. https://doi.org/10.3390/molecules28020732
TDS/COA/MSDS
| Cat. No. | Product | TDS | COA | MSDS |
|---|---|---|---|---|
| SHWE-HSB | Extracellular matrix |
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